CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037114
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family D member 3 
Protein Synonyms/Alias
  
Gene Name
 ABCD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MAAFSKYLTARNSubiquitination[1, 2]
63DHVTHCKKSGKPPLQubiquitination[3]
85KERAVVDKVFFSRLIubiquitination[1, 3, 4]
96SRLIQILKIMVPRTFubiquitination[5]
175KYGLNELKLCFRVRLubiquitination[5]
184CFRVRLTKYLYEEYLubiquitination[5]
198LQAFTYYKMGNLDNRubiquitination[5]
277RLRRPIGKMTITEQKubiquitination[3, 5]
284KMTITEQKYEGEYRYacetylation[6]
284KMTITEQKYEGEYRYubiquitination[1, 2, 3, 4, 5, 7, 8]
310IAFYNGNKREKQTVHubiquitination[1, 2, 3, 5, 7, 8]
371LSHPRHLKSTHSELLubiquitination[1, 3, 4, 5, 8]
423TELMQVLKDLNHGKYubiquitination[3, 5]
429LKDLNHGKYERTMVSubiquitination[3, 5]
503CGPNGCGKSSLFRVLubiquitination[1, 5]
559GREDQKRKGISDLVLubiquitination[1, 3]
567GISDLVLKEYLDNVQubiquitination[3, 5]
600DVLSGGEKQRMAMARubiquitination[1, 3, 5, 8]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 683 AA 
Protein Sequence
MAAFSKYLTA RNSSLAGAAF LLLCLLHKRR RALGLHGYFM ETWREKSDEV MGELTDHVTH 60
CKKSGKPPLQ NNEKEGKKER AVVDKVFFSR LIQILKIMVP RTFCKETGYL VLIAVMLVSR 120
TYCDVWMIQN GTLIESGIIG RSRKDFKRYL LNFIAAMPLI SLVNNFLKYG LNELKLCFRV 180
RLTKYLYEEY LQAFTYYKMG NLDNRIANPD QLLTQDVEKF CNSVVDLYSN LSKPFLDIVL 240
YIFKLTSAIG AQGPASMMAY LVVSGLFLTR LRRPIGKMTI TEQKYEGEYR YVNSRLITNS 300
EEIAFYNGNK REKQTVHSVF RKLVEHLHNF ILFRFSMGFI DSIIAKYLAT VVGYLVVSRP 360
FLDLSHPRHL KSTHSELLED YYQSGRMLLR MSQALGRIVL AGREMTRLAG FTARITELMQ 420
VLKDLNHGKY ERTMVSQQEK GIEGVQVIPL IPGAGEIIIA DNIIKFDHVP LATPNGDVLI 480
RDLNFEVRSG ANVLICGPNG CGKSSLFRVL GELWPLFGGR LTKPERGKLF YVPQRPYMTL 540
GTLRDQVIYP DGREDQKRKG ISDLVLKEYL DNVQLGHILE REGGWDSVQD WMDVLSGGEK 600
QRMAMARLFY HKPQFAILDE CTSAVSVDVE GYIYSHCRKV GITLFTVSHR KSLWKHHEYY 660
LHMDGRGNYE FKQITEDTVE FGS 683 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR010509; ABC_Ald_N.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005283; FA_transporter.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06472; ABC_membrane_2
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS