UniProt Accession

 SECY_ECOLI; P0AGA2; P03844; Q2M6W5 

Genbank Protein ID

 X01563; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA25725.1; AAA58097.1; AAC76325.1; BAE77991.1 

Protein Name

 Protein translocase subunit SecY 

Protein Synonyms/Alias

  

Gene Name

 secY 

Gene Synonyms/Alias

 prlA; b3300; JW3262 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
347	RETADNLKKSGAFVP	acetylation	[1]
364	RPGEQTAKYIDKVMT	acetylation	[1]
368	QTAKYIDKVMTRLTL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY. 

Sequence Annotation

  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 443 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:EcoliWiki.
 GO:0005886; C:plasma membrane; IDA:EcoliWiki.
 GO:0065002; P:intracellular protein transmembrane transport; IMP:EcoliWiki.
 GO:0006605; P:protein targeting; IEA:HAMAP.
 GO:0043952; P:protein transport by the Sec complex; IMP:EcoliWiki. 

Interpro

 IPR026593; SecY.
 IPR002208; SecY/SEC61-alpha.
 IPR023201; SecY_su_dom. 

Pfam

 PF00344; SecY 

SMART

  

PROSITE

 PS00755; SECY_1
 PS00756; SECY_2 

PRINTS