CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily A member 5 
Protein Synonyms/Alias
 HPCN1; Voltage-gated potassium channel HK2; Voltage-gated potassium channel subunit Kv1.5 
Gene Name
 KCNA5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
221REDEGFIKEEEKPLPsumoylation[1]
536HEEPAVLKEEQGTQSsumoylation[1]
Reference
 [1] SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.
 Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR.
 Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1805-10. [PMID: 17261810] 
Functional Description
 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. 
Sequence Annotation
 REPEAT 61 71 1.
 REPEAT 72 82 2.
 REGION 61 82 2 X 11 AA tandem repeat of D-[SP]-G-V-R-
 MOTIF 480 485 Selectivity filter (By similarity).
 MOTIF 611 613 PDZ-binding (By similarity).
 MOD_RES 557 557 Phosphoserine; by PKA (Potential).
 LIPID 346 346 S-palmitoyl cysteine (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CROSSLNK 221 221 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 536 536 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Atrial fibrillation; Complete proteome; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Ubl conjugation; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 613 AA 
Protein Sequence
MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA PKGRGAQRDA 60
DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG DPGLGTVEDQ ALGTASLHHQ 120
RVHINISGLR FETQLGTLAQ FPNTLLGDPA KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ 180
SGGRLRRPVN VSLDVFADEI RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF 240
EYPESSGSAR AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG 300
SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA GFSRNIMNII 360
DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR VIRLVRVFRI FKLSRHSKGL 420
QILGKTLQAS MRELGLLIFF LFIGVILFSS AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT 480
VGYGDMRPIT VGGKIVGSLC AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG 540
TQSQGPGLDR GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL 600
YALCLDTSRE TDL 613 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0014704; C:intercalated disc; IDA:BHF-UCL.
 GO:0045121; C:membrane raft; IDA:BHF-UCL.
 GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL.
 GO:0005251; F:delayed rectifier potassium channel activity; IDA:BHF-UCL.
 GO:0015271; F:outward rectifier potassium channel activity; IDA:BHF-UCL.
 GO:0019870; F:potassium channel inhibitor activity; IEA:Compara.
 GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
 GO:0060081; P:membrane hyperpolarization; IMP:BHF-UCL.
 GO:0043267; P:negative regulation of potassium ion transport; IEA:Compara.
 GO:0071435; P:potassium ion export; IDA:BHF-UCL.
 GO:0055075; P:potassium ion homeostasis; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0051481; P:reduction of cytosolic calcium ion concentration; IEA:Compara.
 GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:0050796; P:regulation of insulin secretion; TAS:BHF-UCL.
 GO:0043266; P:regulation of potassium ion transport; IMP:BHF-UCL.
 GO:0019229; P:regulation of vasoconstriction; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003972; K_chnl_volt-dep_Kv1.
 IPR004052; K_chnl_volt-dep_Kv1.5.
 IPR003131; T1-type_BTB. 
Pfam
 PF00520; Ion_trans
 PF02214; K_tetra 
SMART
 SM00225; BTB 
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01512; KV15CHANNEL.
 PR01491; KVCHANNEL.
 PR01496; SHAKERCHANEL.