CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023626
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trafficking protein particle complex subunit 4 
Protein Synonyms/Alias
 Hematopoietic stem/progenitor cell protein 172; Synbindin; TRS23 homolog 
Gene Name
 TRAPPC4 
Gene Synonyms/Alias
 SBDN; CGI-104; HSPC172; PTD009 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30APRAEAEKTFSYPLDubiquitination[1, 2, 3, 4]
41YPLDLLLKLHDERVLubiquitination[1, 2, 3, 4]
80GRYTADGKEVLEYLGubiquitination[1, 3, 4]
203ELFDQNLKLALEVAEubiquitination[5]
211LALEVAEKAGTFGPGubiquitination[1, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572
Functional Description
 May play a role in vesicular transport from endoplasmic reticulum to Golgi. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 219 AA 
Protein Sequence
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG 60
HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA 120
IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF 180
ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS 219 
Gene Ontology
 GO:0005801; C:cis-Golgi network; IEA:InterPro.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005795; C:Golgi stack; ISS:UniProtKB.
 GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
 GO:0030008; C:TRAPP complex; IEA:Compara.
 GO:0016358; P:dendrite development; ISS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR011012; Longin-like_dom.
 IPR007233; Sybindin. 
Pfam
 PF04099; Sybindin 
SMART
  
PROSITE
  
PRINTS