| Tag | Content |
|---|
| CPLM ID | CPLM-012690 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 74 |
Protein Synonyms/Alias | Zinc finger protein 520; hZNF7 |
Gene Name | ZNF74 |
Gene Synonyms/Alias | ZNF520 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 231 | STPSEPEKFPQVRRQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role in RNA metabolism. |
Sequence Annotation | DOMAIN 43 114 KRAB.
ZN_FING 248 270 C2H2-type 1.
ZN_FING 276 298 C2H2-type 2.
ZN_FING 304 326 C2H2-type 3.
ZN_FING 332 354 C2H2-type 4.
ZN_FING 360 382 C2H2-type 5.
ZN_FING 388 410 C2H2-type 6.
ZN_FING 416 438 C2H2-type 7.
ZN_FING 444 466 C2H2-type 8.
ZN_FING 472 494 C2H2-type 9.
ZN_FING 500 522 C2H2-type 10.
ZN_FING 528 550 C2H2-type 11.
ZN_FING 556 578 C2H2-type 12. |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 644 AA |
Protein Sequence | MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL 60
DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE PWSMQREVPR GPCPEWELKA 120
VPSQQQGICK EEPAQEPIME RPLGGAQAWG RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP 180
LRCPLFAQQR VPEGGPLLDT RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG 240
AGAGEGEFVC GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG 300
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH LRVHTGEKPY 360
RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH SSLTVHEKIH SGDKPFKCSD 420
CEKAFNSRSR LTLHQRTHTG EKPFKCADCG KGFSCHAYLL VHRRIHSGEK PFKCNECGKA 480
FSSHAYLIVH RRIHTGEKPF DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN 540
HCLIKHQKIH SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG 600
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN 644 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007275; P:multicellular organismal development; TAS:ProtInc. GO:0006355; P:regulation of transcription, DNA-dependent; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |