UniProt Accession

 TIAR_HUMAN; Q01085; A8K3T0; A8K4L9 

Genbank Protein ID

 M96954; AK290695; AK290984 

Genbank Nucleotide ID

 AAA36384.1; BAF83384.1; BAF83673.1 

Protein Name

 Nucleolysin TIAR 

Protein Synonyms/Alias

 TIA-1-related protein 

Gene Name

 TIAL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	TTPSSQKKDTSNHFH	ubiquitination	[1]
139	SAFAPFGKISDARVV	ubiquitination	[1, 2]
220	VVNQSSPKNCTVYCG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 

Sequence Annotation

 DOMAIN 9 85 RRM 1.
 DOMAIN 97 175 RRM 2.
 DOMAIN 205 277 RRM 3.
 MOD_RES 122 122 N6-acetyllysine.
 MOD_RES 201 201 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0017091; F:AU-rich element binding; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0017145; P:stem cell division; IEA:Compara. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS