CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tropomyosin alpha-4 chain 
Protein Synonyms/Alias
  
Gene Name
 TPM4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23EIQEMQLKEAKHIAEubiquitination[1]
26EMQLKEAKHIAEEADubiquitination[1]
42KYEEVARKLVILEGEubiquitination[1, 2]
79KNVTNNLKSLEAASEubiquitination[1, 2]
87SLEAASEKYSEKEDKubiquitination[1, 3]
94KYSEKEDKYEEEIKLubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 102 AA 
Protein Sequence
MKVIENRAMK DEEKMEIQEM QLKEAKHIAE EADRKYEEVA RKLVILEGEL ERAEERAEVS 60
ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LL 102 
Gene Ontology
 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0031941; C:filamentous actin; IEA:Compara.
 GO:0002102; C:podosome; IEA:Compara. 
Interpro
 IPR000533; Tropomyosin. 
Pfam
 PF00261; Tropomyosin 
SMART
  
PROSITE
  
PRINTS
 PR00194; TROPOMYOSIN.