CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002425
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-glutamyl phosphate reductase 
Protein Synonyms/Alias
 GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase 
Gene Name
 proA 
Gene Synonyms/Alias
 b0243; JW0233 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
15AAKQASYKLAQLSSRacetylation[1]
164AVIQDALKSCGLPAGacetylation[1]
192SEMLRMDKYIDMLIPacetylation[1]
263VETLLVNKNIADSFLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity). 
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Proline biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MLEQMGIAAK QASYKLAQLS SREKNRVLEK IADELEAQSE IILNANAQDV ADARANGLSE 60
AMLDRLALTP ARLKGIADDV RQVCNLADPV GQVIDGGVLD SGLRLERRRV PLGVIGVIYE 120
ARPNVTVDVA SLCLKTGNAV ILRGGKETCR TNAATVAVIQ DALKSCGLPA GAVQAIDNPD 180
RALVSEMLRM DKYIDMLIPR GGAGLHKLCR EQSTIPVITG GIGVCHIYVD ESVEIAEALK 240
VIVNAKTQRP STCNTVETLL VNKNIADSFL PALSKQMAES GVTLHADAAA LAQLQAGPAK 300
VVAVKAEEYD DEFLSLDLNV KIVSDLDDAI AHIREHGTQH SDAILTRDMR NAQRFVNEVD 360
SSAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLE ALTTYKWIGI GDYTIRA 417 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IDA:EcoCyc.
 GO:0050661; F:NADP binding; IDA:EcoCyc.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006561; P:proline biosynthetic process; IGI:EcoCyc. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR000965; G-glutamylP_reductase.
 IPR020593; G-glutamylP_reductase_CS.
 IPR012134; Glu-5-SA_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS01223; PROA 
PRINTS