CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018183
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotubularin-related protein 6 
Protein Synonyms/Alias
  
Gene Name
 Mtmr6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
226HLLQAISKANPGNRYubiquitination[1]
253IANRAAGKGYENEDNubiquitination[1]
362DSYYRTMKGFMVLIEacetylation[2]
453EELRLKEKTYSLWPFubiquitination[1]
476LNPLYSSKSQRLTVLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells (By similarity). 
Sequence Annotation
 DOMAIN 124 499 Myotubularin phosphatase.
 REGION 248 251 Substrate binding (By similarity).
 REGION 273 274 Substrate binding (By similarity).
 REGION 336 342 Substrate binding (By similarity).
 ACT_SITE 336 336 Phosphocysteine intermediate (By
 BINDING 382 382 Substrate (By similarity).
 MOD_RES 108 108 Phosphotyrosine.
 MOD_RES 557 557 Phosphoserine (By similarity).
 MOD_RES 585 585 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Hydrolase; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MEHIRTTKVE QVKLLDRFST NNKSLTGTLY LTATHLLFID AQQKETWILH HHIASVEKLA 60
LTTSGCPLVI QCKNFRIVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDTE 120
RRNGWQLIDL AAEYERMGVP NANWQLSDAN REYKVCETYP RELYVPRTAS RPVIVGSSNF 180
RSKGRLPVLS YCRQGTEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPG NRYMYVVDTR 240
PKLNAIANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGS KGLSVNDFYS 300
GLESSGWLRH IKAVLDAAIF LAKAIVVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT 360
MKGFMVLIEK DWISFGHKFS ERCGHLDGDP REVSPVFTQF LECVWHLTQQ FPQAFEFNEA 420
FLLQIHEHIH SCQFGNFLGN CQKEREELRL KEKTYSLWPF LLDDKKKYLN PLYSSKSQRL 480
TVLEPNTASF NFKFWRNMYH QFDRTLHPRQ SVLSIIMNMN EQSKQLEEDI KDLEAKIKQC 540
KNGILTKELL HAVHPESPAL KTSLCLKEPS LLPVKDTLRA IEGSSPADNR YCDYAEEFSK 600
SEPTVVSLEY GVARMTC 617 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0015269; F:calcium-activated potassium channel activity; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF06602; Myotub-related 
SMART
  
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS