CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009263
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptosomal-associated protein 25 
Protein Synonyms/Alias
 SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein 
Gene Name
 SNAP25 
Gene Synonyms/Alias
 SNAP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40LQLVEESKDAGIRTLubiquitination[1]
201EANQRATKMLGSG**ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. 
Sequence Annotation
 DOMAIN 19 81 t-SNARE coiled-coil homology 1.
 DOMAIN 140 202 t-SNARE coiled-coil homology 2.
 REGION 1 75 Interaction with CENPF (By similarity).
 MOD_RES 138 138 Phosphothreonine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 LIPID 85 85 S-palmitoyl cysteine (By similarity).
 LIPID 88 88 S-palmitoyl cysteine (By similarity).
 LIPID 90 90 S-palmitoyl cysteine (By similarity).
 LIPID 92 92 S-palmitoyl cysteine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLDRV 60
EEGMNHINQD MKEAEKNLKD LGKCCGLFIC PCNKLKSSDA YKKAWGNNQD GVVASQPARV 120
VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR 180
IMEKADSNKT RIDEANQRAT KMLGSG 206 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; ISS:HGNC.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0031201; C:SNARE complex; IDA:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0014047; P:glutamate secretion; TAS:Reactome.
 GO:0001504; P:neurotransmitter uptake; NAS:UniProtKB.
 GO:0050796; P:regulation of insulin secretion; TAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016081; P:synaptic vesicle docking involved in exocytosis; NAS:UniProtKB. 
Interpro
 IPR000928; SNAP-25.
 IPR000727; T_SNARE_dom. 
Pfam
 PF00835; SNAP-25
 PF05739; SNARE 
SMART
 SM00397; t_SNARE 
PROSITE
 PS50192; T_SNARE 
PRINTS