CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase TTC3 
Protein Synonyms/Alias
  
Gene Name
 TTC3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
949FSEPASLKEARCLIWubiquitination[1]
1079EYVVRNKKLWDMNPKubiquitination[1]
1135LEKAGGLKPFLLGCPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1165 AA 
Protein Sequence
MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 60
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 120
NLKKLQHLEL MEDIVDLAKK VAKILAMEEA LNWIKYAGDV TILTKLGSID NCWPMLSIFF 180
TEYKYHITKI VMEDCNLLEE LKTQSCMDCI EEGELMKMKG NEEFSKERFD IAIIYYTRAI 240
EYRPENYLLY GNRALCFLRT GQFRNALGDG KRATILKNTW PKGHYRYCDA LSMLGEYDWA 300
LQANIKAQKL CKNDPEGIKD LIQQHVKLQK QIEDLQGRTA NKDPIKAFYE NRAYTPRSLS 360
APIFTTSLNF VEKERDFRKI NHEMANGGNQ NLKVADEALK VDDCDCHPEF SPPSSQPPKH 420
KGKQKSRNNE SEKFSSSSPL TLPADLKNIL EKQFSKSSRA AHQDFANIMK MLRSLIQDGY 480
MALLEQRCRS AAQAFTELLN GLDPQKIKQL NLAMINYVLV VYGLAISLLG IGQPEELSEA 540
ENQFKRIIEH YPSEGLDCLA YCGIGKVYLK KNRFLEALNH FEKARTLIYR LPGVLTWPTS 600
NVIIEESQPQ KIKMLLEKFV EECKFPPVPD AICCYQKCHG YSKIQIYITD PDFKGFIRIS 660
CCQYCKIEFH MNCWKKLKTT TFNDKIDKDF LQGICLTPDC EGVISKIIIF SSGGEVKCEF 720
EHKVIKEKVP PRPILKQKCS SLEKLRLKED KKLKRKIQKK EAKKLAQERM EEDLRESNPP 780
KNEEQKETVD NVQRCQFLDD RILQCIKQYA DKIKSGIQNT AMLLKELLSW KVLSTEDYTT 840
CFSSRNFLNE AVDYVIRHLI QENNRVKTRI FLHVLSELKE VEPKLAAWIQ KLNSFGLDAT 900
GTFFSRYGAS LKLLDFSIMT FLWNEKYGHK LDSIEGKQLD YFSEPASLKE ARCLIWLLEE 960
HRDKFPALHS ALDEFFDIMD SRCTVLRKQD SGEAPFSSTK VKNKSKKKKP KDSKPMLVGS 1020
GTTSVTSNNE IITSSEDHSN RNSDSAGPFA VPDHLRQDVE EFEALYDQHS NEYVVRNKKL 1080
WDMNPKQKCS TLYDYFSQFL EEHGPLDMSN KMFSAEYEFF PEETRQILEK AGGLKPFLLG 1140
CPRFVVIDNC IALKKVASRL KKKRK 1165 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS