CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001635
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetylserotonin O-methyltransferase-like protein 
Protein Synonyms/Alias
 ASMTL 
Gene Name
 ASMTL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63GYAMETAKQKALEVAubiquitination[1]
133SEFYEETKVKFSELSubiquitination[1]
393HHRALGKKAEDLFQDubiquitination[1]
567MLVQTEGKERSLGEYubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. 
Sequence Annotation
 REGION 11 223 MAF-like.
 REGION 277 621 ASMT-like.
 ACT_SITE 44 44 Potential.
 MOD_RES 239 239 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 621 AA 
Protein Sequence
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME 60
TAKQKALEVA NRLYQTVGGL ILEKPVDKQD AYRMLSRLSG REHSVFTGVA IVHCSSKDHQ 120
LDTRVSEFYE ETKVKFSELS EELLWEYVHS GEPMDKAGGY GIQALGGMLV ESVHGDFLNV 180
VGFPLNHFCK QLVKLYYPPR PEDLRRSVKH DSIPAADTFE DLSDVEGGGS EPTQRDAGSR 240
DEKAEAGEAG QATAEAECHR TRETLPPFPT RLLELIEGFM LSKGLLTACK LKVFDLLKDE 300
APQKAADIAS KVDASACGME RLLDICAAMG LLEKTEQGYS NTETANVYLA SDGEYSLHGF 360
IMHNNDLTWN LFTYLEFAIR EGTNQHHRAL GKKAEDLFQD AYYQSPETRL RFMRAMHGMT 420
KLTACQVATA FNLSRFSSAC DVGGCTGALA RELAREYPRM QVTVFDLPDI IELAAHFQPP 480
GPQAVQIHFA AGDFFRDPLP SAELYVLCRI LHDWPDDKVH KLLSRVAESC KPGAGLLLVE 540
TLLDEEKRVA QRALMQSLNM LVQTEGKERS LGEYQCLLEL HGFHQVQVVH LGGVLDAILA 600
TKVAP 605 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0008171; F:O-methyltransferase activity; IEA:InterPro. 
Interpro
 IPR025772; ASMT-like.
 IPR003697; Maf.
 IPR001077; O_MeTrfase_2.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF02545; Maf
 PF00891; Methyltransf_2 
SMART
  
PROSITE
  
PRINTS