CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein TRIM6-TRIM34 
Protein Synonyms/Alias
 TRIM6-TRIM34 readthrough transcript 
Gene Name
 TRIM6-TRIM34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
398ACITVSNKEAVTSMGubiquitination[1]
436ANIVERLKEVKLSPDubiquitination[1]
457LCDHHGEKLLLFCKEubiquitination[1]
463EKLLLFCKEDRKVICubiquitination[1]
503EKLQAVLKRLKKEEEubiquitination[2]
527REEKTSWKYQVQTERubiquitination[1, 3]
569EEKKTLDKFAEAEDEubiquitination[1]
581EDELVQQKQLVRELIubiquitination[1, 2, 4, 5]
627KPKMVSKKLKTVFHAacetylation[6]
629KMVSKKLKTVFHAPDacetylation[6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 842 AA 
Protein Sequence
MCGSERILQA GNILEIRVGQ AGARRVATMT SPVLVDIREE VTCPICLELL TEPLSIDCGH 60
SFCQACITPN GRESVIGQEG ERSCPVCQTS YQPGNLRPNR HLANIVRRLR EVVLGPGKQL 120
KAVLCADHGE KLQLFCQEDG KVICWLCERS QEHRGHHTFL VEEVAQEYQE KFQESLKKLK 180
NEEQEAEKLT AFIREKKTSW KNQMEPERCR IQTEFNQLRN ILDRVEQREL KKLEQEEKKG 240
LRIIEEAEND LVHQTQSLRE LISDLERRCQ GSTMELLQDV SDVTERSEFW TLRKPEALPT 300
KLRSMFRAPD LKRMLRVCRE LTDVQSYWAI QGSLTRRERR ASGVRTRRSQ GSSAMASKIL 360
LNVQEEVTCP ICLELLTEPL SLDCGHSLCR ACITVSNKEA VTSMGGKSSC PVCGISYSFE 420
HLQANQHLAN IVERLKEVKL SPDNGKKRDL CDHHGEKLLL FCKEDRKVIC WLCERSQEHR 480
GHHTVLTEEV FKECQEKLQA VLKRLKKEEE EAEKLEADIR EEKTSWKYQV QTERQRIQTE 540
FDQLRSILNN EEQRELQRLE EEEKKTLDKF AEAEDELVQQ KQLVRELISD VECRSQWSTM 600
ELLQDMSGIM KWSEIWRLKK PKMVSKKLKT VFHAPDLSRM LQMFRELTAV RCYWVDVTLN 660
SVNLNLNLVL SEDQRQVISV PIWPFQCYNY GVLGSQYFSS GKHYWEVDVS KKTAWILGVY 720
CRTYSRHMKY VVRRCANRQN LYTKYRPLFG YWVIGLQNKC KYGVFEESLS SDPEVLTLSM 780
AVPPCRVGVF LDYEAGIVSF FNVTSHGSLI YKFSKCCFSQ PVYPYFNPWN CPAPMTLCPP 840
SS 842 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00622; SPRY
 PF00643; zf-B_box 
SMART
 SM00336; BBOX
 SM00184; RING
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS
 PR01407; BUTYPHLNCDUF.