UniProt Accession

 RS18A_YEAST; P0CX55; D6VT75; P35271 

Genbank Protein ID

 U33007; BK006938 

Genbank Nucleotide ID

 AAB64891.1; DAA12285.1 

Protein Name

 40S ribosomal protein S18-A 

Protein Synonyms/Alias

  

Gene Name

 RPS18A 

Gene Synonyms/Alias

 YDR450W; D9461.35 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	VYALTTIKGVGRRYS	acetylation	[1]
36	VYALTTIKGVGRRYS	ubiquitination	[2, 3]
48	RYSNLVCKKADVDLH	ubiquitination	[3]
49	YSNLVCKKADVDLHK	ubiquitination	[2, 3]
56	KADVDLHKRAGELTQ	acetylation	[4]
80	MQNPTHYKIPAWFLN	ubiquitination	[2, 3]
96	QNDITDGKDYHTLAN	acetylation	[1]
96	QNDITDGKDYHTLAN	ubiquitination	[2, 3]
108	LANNVESKLRDDLER	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [4] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 

Functional Description

 Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; NAS:SGD.
 GO:0002181; P:cytoplasmic translation; NAS:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0006407; P:rRNA export from nucleus; IGI:SGD. 

Interpro

 IPR027437; 30s_Rbsml_prot_S13_C.
 IPR001892; Ribosomal_S13.
 IPR010979; Ribosomal_S13-like_H2TH.
 IPR018269; Ribosomal_S13_CS. 

Pfam

 PF00416; Ribosomal_S13 

SMART

  

PROSITE

 PS00646; RIBOSOMAL_S13_1
 PS50159; RIBOSOMAL_S13_2 

PRINTS