UniProt Accession

 METK2_MOUSE; Q3THS6; Q3TL60; Q76LX3 

Genbank Protein ID

 AB070266; AK166671; AK168155 

Genbank Nucleotide ID

 BAD06937.1; BAE38932.1; BAE40120.1 

Protein Name

 S-adenosylmethionine synthase isoform type-2 

Protein Synonyms/Alias

 AdoMet synthase 2; Methionine adenosyltransferase 2; MAT 2 

Gene Name

 Mat2a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
81	RAAIDYQKVVREAIK	acetylation	[1]
81	RAAIDYQKVVREAIK	ubiquitination	[2]
88	KVVREAIKHIGYDDS	acetylation	[1]
97	IGYDDSSKGFDYKTC	acetylation	[3]
97	IGYDDSSKGFDYKTC	ubiquitination	[2]
228	ALKEKVIKAVVPAKY	acetylation	[1]
228	ALKEKVIKAVVPAKY	ubiquitination	[2]
234	IKAVVPAKYLDEDTI	acetylation	[1]
234	IKAVVPAKYLDEDTI	ubiquitination	[2]
265	DAGLTGRKIIVDTYG	ubiquitination	[2]
285	GGGAFSGKDYTKVDR	ubiquitination	[2]
303	YAARWVAKSLVKGGL	ubiquitination	[2]
350	RELLEIVKKNFDLRP	ubiquitination	[2]
351	ELLEIVKKNFDLRPG	acetylation	[1]
351	ELLEIVKKNFDLRPG	ubiquitination	[2]
367	IVRDLDLKKPIYQRT	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity). 

Sequence Annotation

 NP_BIND 131 136 ATP (Potential).
 METAL 31 31 Magnesium (By similarity).
 METAL 57 57 Potassium (By similarity).
 METAL 283 283 Potassium (By similarity).
 METAL 291 291 Magnesium (By similarity).
 BINDING 159 159 ATP (Potential).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 114 114 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Cobalt; Complete proteome; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Phosphoprotein; Potassium; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004478; F:methionine adenosyltransferase activity; IDA:MGI.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0006556; P:S-adenosylmethionine biosynthetic process; IDA:MGI. 

Interpro

 IPR022631; ADOMET_SYNTHASE_CS.
 IPR022630; S-AdoMet_synt_C.
 IPR022629; S-AdoMet_synt_central.
 IPR022628; S-AdoMet_synt_N.
 IPR002133; S-AdoMet_synthetase.
 IPR022636; S-AdoMet_synthetase_sfam. 

Pfam

 PF02773; S-AdoMet_synt_C
 PF02772; S-AdoMet_synt_M
 PF00438; S-AdoMet_synt_N 

SMART

  

PROSITE

 PS00376; ADOMET_SYNTHASE_1
 PS00377; ADOMET_SYNTHASE_2 

PRINTS