UniProt Accession

 YRB1_YEAST; P41920; D6VRY9 

Genbank Protein ID

 Z33503; X65925; L38489; Z48008; BK006938 

Genbank Nucleotide ID

 CAA83911.1; AAA57276.1; CAA88062.1; DAA11849.1 

Protein Name

 Ran-specific GTPase-activating protein 1 

Protein Synonyms/Alias

 Chromosome stability protein 20; Perinuclear array-localized protein; Ran-binding protein 1; RANBP1 

Gene Name

 YRB1 

Gene Synonyms/Alias

 CST20; HTN1; SFO1; YDR002W; YD8119.08 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
77	HLEKVDVKTMEEDEE	ubiquitination	[1]
88	EDEEVLYKVRAKLFR	acetylation	[2]
88	EDEEVLYKVRAKLFR	ubiquitination	[1]
101	FRFDADAKEWKERGT	acetylation	[2]
101	FRFDADAKEWKERGT	ubiquitination	[1]
112	ERGTGDCKFLKNKKT	acetylation	[2]
112	ERGTGDCKFLKNKKT	ubiquitination	[1]
147	IAPEYTLKPNVGSDR	acetylation	[2]
147	IAPEYTLKPNVGSDR	ubiquitination	[1]
188	KENADKFKEEFEKAQ	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2. 

Sequence Annotation

 DOMAIN 64 200 RanBD1.
 MOD_RES 60 60 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; GTPase activation; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0008536; F:Ran GTPase binding; IDA:SGD.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0006606; P:protein import into nucleus; IMP:SGD.
 GO:0006405; P:RNA export from nucleus; IMP:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD. 

Interpro

 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom. 

Pfam

 PF00638; Ran_BP1 

SMART

 SM00160; RanBD 

PROSITE

 PS50196; RANBD1 

PRINTS