CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021788
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier organic anion transporter family member 1B2 
Protein Synonyms/Alias
 Liver-specific organic anion transporter 1; LST-1; SLC21A6; Solute carrier family 21 member 10 
Gene Name
 Slco1b2 
Gene Synonyms/Alias
 Oatp1b2; Slc21a10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9DQTQHPSKAAQPLRSubiquitination[1]
47ALGGVIMKSSITQIEubiquitination[1]
286KRSQKERKNSASLHVubiquitination[1]
295SASLHVLKTDEDKNPubiquitination[1]
300VLKTDEDKNPVTNPTubiquitination[1]
311TNPTTQEKQAPANLTubiquitination[1]
564RSVQPELKSLGMGFHubiquitination[1]
597LIDRTCMKWSVTSCGubiquitination[1]
653KMKRNDNKILENGRKubiquitination[1]
660KILENGRKFTDEGNPubiquitination[1]
683SCVPSDEKNSETPL*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2 (By similarity). 
Sequence Annotation
 DOMAIN 448 505 Kazal-like.
 MOD_RES 288 288 Phosphoserine.
 MOD_RES 290 290 Phosphoserine.
 CARBOHYD 132 132 N-linked (GlcNAc...) (Potential).
 CARBOHYD 140 140 N-linked (GlcNAc...) (Potential).
 CARBOHYD 513 513 N-linked (GlcNAc...) (Potential).
 DISULFID 454 480 By similarity.
 DISULFID 458 469 By similarity.
 DISULFID 460 484 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 689 AA 
Protein Sequence
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI TQIERRFDIP 60
SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF IMGIGSILTA LPHFFMGYYR 120
YATENDISSL HNSTLTCLVN QTTSLTGTSP EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE 180
TPIVPLGVSY IDDFAKEGNS SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV 240
RITPQDARWV GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK 300
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS FTYLFKFIEQ 360
QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL GITKFVFFTT TMAYVFYLSY 420
FLLICENKAF AGLTLTYDGM NPVDSHIDVP LSYCNSDCIC DKNQWEPVCG ENGVTYISPC 480
LAGCKSFRGD KKLMNIEFYD CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII 540
SFFTALGSTS LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV 600
TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN DNKILENGRK 660
FTDEGNPEPV NNNGYSCVPS DEKNSETPL 689 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; ISS:MGI.
 GO:0015125; F:bile acid transmembrane transporter activity; IEA:Compara.
 GO:0015238; F:drug transmembrane transporter activity; IEA:Compara.
 GO:0015198; F:oligopeptide transporter activity; IEA:Compara.
 GO:0008514; F:organic anion transmembrane transporter activity; ISS:MGI.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. 
Interpro
 IPR002350; Kazal_dom.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004156; OA_transporter. 
Pfam
 PF07648; Kazal_2
 PF03137; OATP 
SMART
 SM00280; KAZAL 
PROSITE
 PS51465; KAZAL_2
 PS50850; MFS 
PRINTS