CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022151
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCHC domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 ZCCHC3 
Gene Synonyms/Alias
 C20orf99 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45MGWAQVVKNLAEKKGubiquitination[1]
222VSFRSAEKLALFLRVubiquitination[2]
275EDIVTWLKRHCDVLAubiquitination[3]
330ERGYSWYKGQPKTCFubiquitination[2, 4]
369HLSPYCRKGIVCNLCubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 ZN_FING 334 351 CCHC-type 1.
 ZN_FING 352 369 CCHC-type 2.
 ZN_FING 371 388 CCHC-type 3.
 MOD_RES 202 202 Phosphotyrosine.
 CROSSLNK 45 45 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Isopeptide bond; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MATGGGAEEE RKRGRPQLLP PARPAARGEE ADGGREKMGW AQVVKNLAEK KGEFREPRPP 60
RREEESGGGG GSAGLGGPAG LAAPDLGDFP PAGRGDPKGR RRDPAGEAVD PRKKKGAAEA 120
GRRKKAEAAA AAMATPARPG EAEDAAERPL QDEPAAAAAG PGKGRFLVRI CFQGDEGACP 180
TRDFVVGALI LRSIGMDPSD IYAVIQIPGS REFDVSFRSA EKLALFLRVY EEKREQEDCW 240
ENFVVLGRSK SSLKTLFILF RNETVDVEDI VTWLKRHCDV LAVPVKVTDR FGIWTGEYKC 300
EIELRQGEGG VRHLPGAFFL GAERGYSWYK GQPKTCFKCG SRTHMSGSCT QDRCFRCGEE 360
GHLSPYCRKG IVCNLCGKRG HAFAQCPKAV HNSVAAQLTG VAGH 404 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001878; Znf_CCHC. 
Pfam
 PF00098; zf-CCHC 
SMART
 SM00343; ZnF_C2HC 
PROSITE
 PS50158; ZF_CCHC 
PRINTS