UniProt Accession

 SV422_HUMAN; Q86Y97; Q8WZ10; Q9BRZ6 

Genbank Protein ID

 AC020922; BC005842; BC019313; BC044889; AF289582 

Genbank Nucleotide ID

 AAH05842.1; AAH19313.1; AAH44889.1; AAL55766.1 

Protein Name

 Histone-lysine N-methyltransferase SUV420H2 

Protein Synonyms/Alias

 Lysine N-methyltransferase 5C; Suppressor of variegation 4-20 homolog 2; Su(var)4-20 homolog 2; Suv4-20h2 

Gene Name

 SUV420H2 

Gene Synonyms/Alias

 KMT5C; PP7130 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	SMETNGAKIVSTRAW	ubiquitination	[1, 2, 3]
202	DGNAACVKVLRDIEP	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). 

Sequence Annotation

 DOMAIN 104 218 SET.
 REGION 346 435 Required for heterochromatin localization
 MOD_RES 416 416 Phosphothreonine.
 MOD_RES 422 422 Phosphothreonine.  

Keyword

 3D-structure; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 462 AA 

Protein Sequence

Gene Ontology

 GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Compara.
 GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:Compara.
 GO:0034773; P:histone H4-K20 trimethylation; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR025790; Hist-Lys_N-MTase_Suvar4-20.
 IPR001214; SET_dom. 

Pfam

 PF00856; SET 

SMART

 SM00317; SET 

PROSITE

 PS51570; SAM_MT43_SUVAR420_2
 PS50280; SET 

PRINTS