UniProt Accession

 EMD_MOUSE; O08579 

Genbank Protein ID

 U79753; U73902 

Genbank Nucleotide ID

 AAB51239.1; AAD00238.1 

Protein Name

 Emerin 

Protein Synonyms/Alias

  

Gene Name

 Emd 

Gene Synonyms/Alias

 Sta 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	TRKLYEKKIFEYETQ	ubiquitination	[1]
80	DMYDLPKKEDALLYQ	ubiquitination	[1]
116	PESVGMSKSFRQPGT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity). 

Sequence Annotation

 DOMAIN 1 45 LEM.
 REGION 46 223 Interaction with F-actin (By similarity).
 REGION 168 187 Interaction with CTNNB1 (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 54 54 Phosphoserine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphotyrosine.  

Keyword

 Acetylation; Actin-binding; Complete proteome; Membrane; Microtubule; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; TAS:MGI.
 GO:0005652; C:nuclear lamina; TAS:MGI.
 GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0035414; P:negative regulation of catenin import into nucleus; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0046827; P:positive regulation of protein export from nucleus; IEA:Compara.
 GO:0060828; P:regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI. 

Interpro

 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom. 

Pfam

 PF03020; LEM 

SMART

 SM00540; LEM 

PROSITE

 PS50954; LEM 

PRINTS