UniProt Accession

 CAV1_HUMAN; Q03135; Q9UGP1; Q9UNG1; Q9UQH6 

Genbank Protein ID

 Z18951; AF095593; AF095591; AF095592; AJ133269; AF125348; BT007143; BC009685; BC082246 

Genbank Nucleotide ID

 CAA79476.1; AAD23745.1; AAD23745.1; AAD23745.1; CAB63654.1; AAD34722.1; AAP35807.1; AAH09685.1; AAH82246.1 

Protein Name

 Caveolin-1 

Protein Synonyms/Alias

  

Gene Name

 CAV1 

Gene Synonyms/Alias

 CAV 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MADELSEKQVYDAHT	ubiquitination	[1, 2, 3]
16	QVYDAHTKEIDLVNR	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 5 5 N6-acetyllysine.
 MOD_RES 6 6 Phosphotyrosine.
 MOD_RES 14 14 Phosphotyrosine; by ABL1.
 MOD_RES 25 25 Phosphotyrosine.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 42 42 Phosphotyrosine.
 LIPID 133 133 S-palmitoyl cysteine (By similarity).
 LIPID 143 143 S-palmitoyl cysteine (By similarity).
 LIPID 156 156 S-palmitoyl cysteine (By similarity).  

Keyword

 Acetylation; Alternative initiation; Cell membrane; Complete proteome; Congenital generalized lipodystrophy; Direct protein sequencing; Disease mutation; Golgi apparatus; Host-virus interaction; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0002080; C:acrosomal membrane; IEA:Compara.
 GO:0016324; C:apical plasma membrane; IDA:BHF-UCL.
 GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL.
 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IDA:HGNC.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005811; C:lipid particle; TAS:Reactome.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0015485; F:cholesterol binding; TAS:HGNC.
 GO:0016504; F:peptidase activator activity; ISS:BHF-UCL.
 GO:0032947; F:protein complex scaffold; TAS:BHF-UCL.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0097190; P:apoptotic signaling pathway; IMP:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006816; P:calcium ion transport; ISS:BHF-UCL.
 GO:0070836; P:caveola assembly; IMP:BHF-UCL.
 GO:0072584; P:caveolin-mediated endocytosis; IDA:UniProtKB.
 GO:0071455; P:cellular response to hyperoxia; IMP:UniProtKB.
 GO:0009267; P:cellular response to starvation; IEP:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.
 GO:0030301; P:cholesterol transport; TAS:HGNC.
 GO:0051480; P:cytosolic calcium ion homeostasis; IDA:BHF-UCL.
 GO:0000188; P:inactivation of MAPK activity; ISS:BHF-UCL.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0019915; P:lipid storage; ISS:BHF-UCL.
 GO:0032507; P:maintenance of protein location in cell; ISS:BHF-UCL.
 GO:0060056; P:mammary gland involution; ISS:BHF-UCL.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0051899; P:membrane depolarization; ISS:BHF-UCL.
 GO:2000811; P:negative regulation of anoikis; IMP:UniProtKB.
 GO:0030514; P:negative regulation of BMP signaling pathway; IDA:BHF-UCL.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:BHF-UCL.
 GO:0030857; P:negative regulation of epithelial cell differentiation; ISS:BHF-UCL.
 GO:0046426; P:negative regulation of JAK-STAT cascade; ISS:BHF-UCL.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0031397; P:negative regulation of protein ubiquitination; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
 GO:0033484; P:nitric oxide homeostasis; ISS:BHF-UCL.
 GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; ISS:BHF-UCL.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0048554; P:positive regulation of metalloenzyme activity; ISS:BHF-UCL.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:0045907; P:positive regulation of vasoconstriction; ISS:BHF-UCL.
 GO:0051260; P:protein homooligomerization; ISS:BHF-UCL.
 GO:2000286; P:receptor internalization involved in canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0030193; P:regulation of blood coagulation; IMP:BHF-UCL.
 GO:0019217; P:regulation of fatty acid metabolic process; ISS:BHF-UCL.
 GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.
 GO:0006940; P:regulation of smooth muscle contraction; ISS:BHF-UCL.
 GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Compara.
 GO:0051592; P:response to calcium ion; ISS:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IDA:MGI.
 GO:0001666; P:response to hypoxia; ISS:BHF-UCL.
 GO:0002931; P:response to ischemia; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IDA:MGI.
 GO:0007519; P:skeletal muscle tissue development; ISS:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0031295; P:T cell costimulation; IDA:UniProtKB.
 GO:0006641; P:triglyceride metabolic process; ISS:BHF-UCL.
 GO:0001570; P:vasculogenesis; ISS:BHF-UCL.
 GO:0042310; P:vasoconstriction; IEA:Compara.
 GO:0016050; P:vesicle organization; IDA:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR001612; Caveolin.
 IPR015504; Caveolin_1.
 IPR018361; Caveolin_CS. 

Pfam

 PF01146; Caveolin 

SMART

  

PROSITE

 PS01210; CAVEOLIN 

PRINTS