CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001265
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonuclease P protein subunit p20 
Protein Synonyms/Alias
 RNaseP protein p20; Ribonucleases P/MRP protein subunit POP7 homolog; hPOP7 
Gene Name
 POP7 
Gene Synonyms/Alias
 RPP20 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42NDIYVNMKTDFKAQLubiquitination[1, 2, 3]
46VNMKTDFKAQLARCQubiquitination[1, 3, 4, 5]
54AQLARCQKLLDGGARubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Hydrolase; Nucleus; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 140 AA 
Protein Sequence
MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA 60
RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDTREP 120
LTRIRNNSAI HIRVFRVTPK 140 
Gene Ontology
 GO:0005655; C:nucleolar ribonuclease P complex; TAS:ProtInc.
 GO:0004526; F:ribonuclease P activity; TAS:ProtInc.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR014612; RNase_P/MRP_p20. 
Pfam
  
SMART
  
PROSITE
  
PRINTS