| Tag | Content |
|---|
| CPLM ID | CPLM-023896 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protocadherin beta-2 |
Protein Synonyms/Alias | PCDH-beta-2 |
Gene Name | PCDHB2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 299 | KTFRLSAKSGELLLR | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Sequence Annotation | DOMAIN 37 135 Cadherin 1.
DOMAIN 136 244 Cadherin 2.
DOMAIN 249 349 Cadherin 3.
DOMAIN 354 453 Cadherin 4.
DOMAIN 458 563 Cadherin 5.
DOMAIN 570 673 Cadherin 6.
MOD_RES 299 299 N6-acetyllysine.
CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
CARBOHYD 438 438 N-linked (GlcNAc...) (Potential).
CARBOHYD 569 569 N-linked (GlcNAc...) (Potential). |
Keyword | Acetylation; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 798 AA |
Protein Sequence | MEAGEGKERV PKQRQVLIFF VLLGIAQASC QPRHYSVAEE TESGSFVANL LKDLGLEIGE 60
LAVRGARVVS KGKKMHLQFD RQTGDLLLNE KLDREELCGP TEPCVLPFQV LLENPLQFFQ 120
AELRIRDVND HSPVFLDKEI LLKIPESITP GTTFLIERAQ DLDVGTNSLQ NYTISPNFHF 180
HLNLQDSLDG IILPQLVLNR ALDREEQPEI RLTLTALDGG SPPRSGTALV RIEVVDINDN 240
VPEFAKLLYE VQIPEDSPVG SQVAIVSARD LDIGTNGEIS YAFSQASEDI RKTFRLSAKS 300
GELLLRQKLD FESIQTYTVN IQATDGGGLS GTCVVFVQVM DLNDNPPELT MSTLINQIPE 360
NLQDTLIAVF SVSDPDSGDN GRMVCSIQDD LPFFLKPSVE NFYTLVISTA LDRETRSEYN 420
ITITVTDFGT PRLKTEHNIT VLVSDVNDNA PAFTQTSYTL FVRENNSPAL HIGSVSATDR 480
DSGTNAQVTY SLLPPQDPHL PLASLVSINA DNGHLFALQS LDYEALQAFE FRVGAADRGS 540
PALSSEALVR VLVLDANDNS PFVLYPLQNG SAPCTELVPR AAEPGYLVTK VVAVDGDSGQ 600
NAWLSYQLLK ATEPGLFGVW AHNGEVRTAR LLRERDAAKQ RLVVLVKDNG EPPRSATATL 660
HVLLVDGFSQ PYLLLPEAAP AQAQADLLTV YLVVALASVS SLFLFSVLLF VAVRLCRRSR 720
AASVGRCSVP EGPFPGQMVD VSGTGTLSQS YQYEVCLTGG SGTNEFKFLK PIIPNFVAQG 780
AERVSEANPS FRKSFEFT 798 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0016339; P:calcium-dependent cell-cell adhesion; NAS:UniProtKB. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0007416; P:synapse assembly; TAS:UniProtKB. GO:0007268; P:synaptic transmission; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |