UniProt Accession

 LLR1_HUMAN; Q96L50; A5D6X3; B4DDE0; Q52M24; Q86SZ1; Q8N6H9 

Genbank Protein ID

 AY052405; BX248298; AK293156; CH471078; BC030142; BC093697; BC112241; BC139921 

Genbank Nucleotide ID

 AAL11430.1; CAD62625.1; BAG56701.1; EAW65761.1; AAH30142.1; AAH93697.1; AAI12242.1; AAI39922.1 

Protein Name

 Leucine-rich repeat protein 1 

Protein Synonyms/Alias

 4-1BB-mediated-signaling molecule; 4-1BBlrr; LRR-repeat protein 1; LRR-1; Peptidylprolyl isomerase-like 5 

Gene Name

 LRR1 

Gene Synonyms/Alias

 PPIL5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	NIEQFFTKFVDEGKA	ubiquitination	[1]
78	TKFVDEGKATVRLKE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 REPEAT 155 176 LRR 1.
 REPEAT 178 199 LRR 2.
 REPEAT 201 222 LRR 3.
 REPEAT 227 248 LRR 4.
 REPEAT 250 271 LRR 5.
 REPEAT 273 294 LRR 6.
 REPEAT 295 316 LRR 7.  

Keyword

 Alternative splicing; Complete proteome; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 

Pfam

 PF00560; LRR_1
 PF12799; LRR_4 

SMART

  

PROSITE

 PS51450; LRR 

PRINTS