CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017113
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SET and MYND domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 SMYD4 
Gene Synonyms/Alias
 KIAA1936 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53PEDELFLKRLSKGYLubiquitination[1]
57LFLKRLSKGYLVGKDubiquitination[1]
149QPKIMLRKAECLVALubiquitination[1]
243GLCVDPLKGRCLVATubiquitination[1]
377LCDKISNKDICLPESubiquitination[1]
389PESNNQVKTLNYGLGubiquitination[1]
666QQVRVAQKLLRDGELubiquitination[1]
717AALGDWQKSATHLQRubiquitination[1]
789IQELQKMKSCLLDLPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 233 574 SET.
 ZN_FING 296 335 MYND-type.
 REGION 112 114 S-adenosyl-L-methionine binding (By
 REGION 539 540 S-adenosyl-L-methionine binding (By
 BINDING 427 427 S-adenosyl-L-methionine (By similarity).
 BINDING 573 573 S-adenosyl-L-methionine (By similarity).
 BINDING 595 595 S-adenosyl-L-methionine (By similarity).  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 804 AA 
Protein Sequence
MDLPVDEWKS YLLQKWASLP TSVQVTISTA ETLRDIFLHS SSLLQPEDEL FLKRLSKGYL 60
VGKDSDAPLF YREEGNKKFQ EKDYTGAAVL YSKGVSHSRP NTEDMSLCHA NRSAALFHLG 120
QYETCLKDIN RAQTHGYPER LQPKIMLRKA ECLVALGRLQ EASQTISDLE RNFTATPALA 180
DVLPQTLQRN LHRLKMKMQE KDSLTESFPA ALAKTLEDAA LREENEQLSN ASSSIGLCVD 240
PLKGRCLVAT KDILPGELLV QEDAFVSVLN PGELPPPHHG LDSKWDTRVT NGDLYCHRCL 300
KHTLATVPCD GCSYAKYCSQ ECLQQAWELY HRTECPLGGL LLTLGVFCHI ALRLTLLVGF 360
EDVRKIITKL CDKISNKDIC LPESNNQVKT LNYGLGESEK NGNIVETPIP GCDINGKYEN 420
NYNAVFNLLP HTENHSPEHK FLCALCVSAL CRQLEAASLQ AIPTERIVNS SQLKAAVTPE 480
LCPDVTIWGV AMLRHMLQLQ CNAQAMTTIQ HTGPKGSIVT DSRQVRLATG IFPVISLLNH 540
SCSPNTSVSF ISTVATIRAS QRIRKGQEIL HCYGPHKSRM GVAERQQKLR SQYFFDCACP 600
ACQTEAHRMA AGPRWEAFCC NSCGAPMQGD DVLRCGSRSC AESAVSRDHL VSRLQDLQQQ 660
VRVAQKLLRD GELERAVQRL SGCQRDAESF LWAEHAVVGE IADGLARACA ALGDWQKSAT 720
HLQRSLYVVE VRHGPSSVEM GHELFKLAQI FFNGFAVPEA LSTIQKAEEV LSLHCGPWDD 780
EIQELQKMKS CLLDLPPTPV GPAL 804 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001214; SET_dom.
 IPR011990; TPR-like_helical.
 IPR002893; Znf_MYND. 
Pfam
 PF00856; SET
 PF01753; zf-MYND 
SMART
 SM00317; SET 
PROSITE
 PS50280; SET
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 
PRINTS