UniProt Accession

 BCAT1_RAT; P54690 

Genbank Protein ID

 U35774; BC087710 

Genbank Nucleotide ID

 AAC52385.1; AAH87710.1 

Protein Name

 Branched-chain-amino-acid aminotransferase, cytosolic 

Protein Synonyms/Alias

 BCAT(c) 

Gene Name

 Bcat1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
53	STQTFRAKDLIITKA	ubiquitination	[1]
59	AKDLIITKADVLKKK	acetylation	[2]
59	AKDLIITKADVLKKK	ubiquitination	[1]
240	PKFVRSWKGGTGDFK	acetylation	[2]
393	LSSRIMAKLTDIQYG	acetylation	[2]
393	LSSRIMAKLTDIQYG	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. 

Sequence Annotation

 MOD_RES 247 247 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004084; F:branched-chain-amino-acid transaminase activity; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0052656; F:L-isoleucine transaminase activity; IEA:EC.
 GO:0052654; F:L-leucine transaminase activity; IEA:EC.
 GO:0052655; F:L-valine transaminase activity; IEA:EC.
 GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0009083; P:branched-chain amino acid catabolic process; IEA:Compara. 

Interpro

 IPR001544; Aminotrans_IV.
 IPR018300; Aminotrans_IV_CS.
 IPR005786; B_amino_transII. 

Pfam

 PF01063; Aminotran_4 

SMART

  

PROSITE

 PS00770; AA_TRANSFER_CLASS_4 

PRINTS