UniProt Accession

 XBP1_MOUSE; O35426; Q8VHM0; Q922G5; Q9ESS3 

Genbank Protein ID

 AB036745; AF443192; AF027963; AL662876; BC008153; BC029197 

Genbank Nucleotide ID

 BAB13793.1; AAL60202.1; AAB81862.2; CAI24935.1; AAH08153.1; AAH29197.1 

Protein Name

 X-box-binding protein 1 

Protein Synonyms/Alias

 XBP-1; Tax-responsive element-binding protein 5 homolog 

Gene Name

 Xbp1 

Gene Synonyms/Alias

 Treb5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
276	SQTNVVVKIEEAPLS	sumoylation	[1]
297	PEFIVSVKKEPLEDD	sumoylation	[1]

Reference

 [1] SUMO modification regulates the transcriptional activity of XBP1.
 Chen H, Qi L.
 Biochem J. 2010 Jul 1;429(1):95-102. [PMID: 20408817] 

Functional Description

 Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE) (By similarity). Isoform 2 is involved in controlling the production of interleukin-6. 

Sequence Annotation

 DOMAIN 63 126 bZIP.
 REGION 65 87 Basic motif (By similarity).
 REGION 91 126 Leucine-zipper (By similarity).  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Compara.
 GO:0060691; P:epithelial cell maturation involved in salivary gland development; IMP:MGI.
 GO:0031017; P:exocrine pancreas development; IMP:MGI.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0060096; P:serotonin secretion, neurotransmission; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR004827; bZIP. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS