Tag | Content |
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CPLM ID | CPLM-004194 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/potassium-transporting ATPase subunit beta-1 |
Protein Synonyms/Alias | Sodium/potassium-dependent ATPase subunit beta-1 |
Gene Name | Atp1b1 |
Gene Synonyms/Alias | Atp4b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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14 | KEEGSWKKFIWNSEK | ubiquitination | [1] | 21 | KFIWNSEKKEFLGRT | ubiquitination | [1] | 217 | LPVQCTGKRDEDKDK | ubiquitination | [1] | 289 | ENIGYSEKDRFQGRF | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. |
Sequence Annotation | REGION 191 304 immunoglobulin-like (By similarity). MOD_RES 101 101 Phosphotyrosine. CARBOHYD 158 158 N-linked (GlcNAc...). CARBOHYD 163 163 N-linked (GlcNAc...); atypical. CARBOHYD 193 193 N-linked (GlcNAc...) (By similarity). CARBOHYD 266 266 N-linked (GlcNAc...). DISULFID 126 149 By similarity. DISULFID 159 175 By similarity. DISULFID 214 277 By similarity. |
Keyword | Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 304 AA |
Protein Sequence | MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT 60 ISELKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA YVLNIIRFLE KYKDSAQKDD 120 MIFEDCGNVP SEPKERGDIN HERGERKVCR FKLDWLGNCS GLNDDSYGYR EGKPCIIIKL 180 NRVLGFKPKP PKNESLETYP LMMKYNPNVL PVQCTGKRDE DKDKVGNIEY FGMGGYYGFP 240 LQYYPYYGKL LQPKYLQPLL AVQFTNLTVD TEIRVECKAY GENIGYSEKD RFQGRFDVKI 300 EIKS 304 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016323; C:basolateral plasma membrane; IDA:MGI. GO:0005901; C:caveola; IEA:Compara. GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Compara. GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:Compara. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0001666; P:response to hypoxia; IEA:Compara. |
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