CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5'-nucleotidase domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Nt5dc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
142KYPEGIRKYDYDPSFacetylation[1]
210QMSGFYGKGPSIKQFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 106 106 Nucleophile (By similarity).
 ACT_SITE 108 108 Proton donor (By similarity).
 METAL 106 106 Magnesium (By similarity).
 METAL 108 108 Magnesium; via carbonyl oxygen (By
 METAL 391 391 Magnesium (By similarity).  
Keyword
 Complete proteome; Hydrolase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MAGAGLRAAA RRWLLCGGQG GPRAASSSPS CPGCGPPGPG AHCPSTPRSA PADGADLSAH 60
LWARYQDMRR LVHDLLPPEV CSLLNPAAIY ANNEISLSDV EVYGFDYDYT LAQYADALHP 120
EIFSAARDIL IEHYKYPEGI RKYDYDPSFA IRGLHYDIQK SLLMKIDAFH YVQLGTAYRG 180
LQPVPDDEVV DLYGGTQHIP LYQMSGFYGK GPSIKQFMDI FSLPEMALLS CVVDYFLGHG 240
LEFDQVHLYK DVTDAIRDVH VKGLMYQWIE QDMEKYILRG DETFAVLSRL VAHGKQLFLI 300
TNSPFSFVDK GMRHMVGPDW RQLFDVVIVQ ADKPNFFTDR RKPFRKLDEK GSLHWDRITR 360
LEKGKIYRQG NLFDFLRLTE WRGPRVLYFG DHLYSDLADL MLRHGWRTGA IIPELEREIR 420
IINTEQYMHS LTWQQALTGL LERMQTYQDA ESRQVLATWM KERQELRCIT KALFNAQFGS 480
IFRTFHNPTY FSRRLVRFSD LYMASLSCLL NYSVDFTFYP RRTPLQHEAP LWMDQLCTGC 540
MKTPFLGDMA HIR 553 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR023214; HAD-like_dom.
 IPR008380; HAD-SF_hydro_IG_5-nucl.
 IPR016695; Pur_nucleotidase. 
Pfam
 PF05761; 5_nucleotid 
SMART
  
PROSITE
  
PRINTS