UniProt Accession

 E9Q740_MOUSE; E9Q740 

Genbank Protein ID

 AC114666 

Genbank Nucleotide ID

  

Protein Name

 Signal recognition particle subunit SRP72 

Protein Synonyms/Alias

  

Gene Name

 Srp72 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
84	NNSLSFEKAYCEYRL	acetylation	[1]
110	SATQQTDKLKELYGQ	acetylation	[1]
112	TQQTDKLKELYGQVL	ubiquitination	[2]
201	QAMKILQKAEDLCRR	acetylation	[1]
236	NAEGVEFKLSKRQLQ	ubiquitination	[2]
322	KLTMAQLKISQGNIS	ubiquitination	[2]
330	ISQGNISKACLILRS	acetylation	[1]
330	ISQGNISKACLILRS	ubiquitination	[2]
418	QLWKQNSKDIHTLAQ	ubiquitination	[2]
437	YSLVDPEKAKALSKH	ubiquitination	[2]
508	LPKNYDPKVTPDPER	acetylation	[3]
508	LPKNYDPKVTPDPER	ubiquitination	[2]
539	KKKDQIGKGTQGATA	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; Signal recognition particle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 610 AA 

Protein Sequence

Gene Ontology

 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; ISA:MGI.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; ISA:MGI. 

Interpro

 IPR013699; Signal_recog_part_SRP72_RNA-bd.
 IPR026270; SRP72.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF08492; SRP72
 PF13174; TPR_6 

SMART

  

PROSITE

  

PRINTS