| Tag | Content |
|---|
| CPLM ID | CPLM-019767 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Docking protein 1 |
Protein Synonyms/Alias | Downstream of tyrosine kinase 1; p62(dok); pp62 |
Gene Name | DOK1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 46 | RLEFFDHKGSSSGGG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
Sequence Annotation | DOMAIN 4 119 PH.
DOMAIN 151 259 IRS-type PTB.
MOD_RES 269 269 Phosphoserine.
MOD_RES 291 291 Phosphoserine.
MOD_RES 296 296 Phosphotyrosine (By similarity).
MOD_RES 315 315 Phosphotyrosine (By similarity).
MOD_RES 337 337 Phosphotyrosine (By similarity).
MOD_RES 341 341 Phosphotyrosine.
MOD_RES 362 362 Phosphotyrosine; by INSR.
MOD_RES 377 377 Phosphotyrosine.
MOD_RES 398 398 Phosphotyrosine; by INSR.
MOD_RES 409 409 Phosphotyrosine.
MOD_RES 449 449 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Acetylation; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGSSRRL 60
DCKVIRLAEC VSVAPVTVET PPEPGATAFR LDTAQRSHLL AADAPSSAAW VQTLCRNAFP 120
KGSWTLAPTD NPPKLSALEM LENSLYSPTW EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA 180
ERLTLLTVGA QSQILEPLLS WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND 240
IFQAVETAIH RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL 300
DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK AKLTDPKEDP 360
IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL PYNPATDDYA VPPPRSTKPL 420
LAPKPQGPAF PEPGTATGSG IKSHNSALYS QVQKSGASGS WDCGLSRVGT DKTGVKSEGS 480
T 481 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005057; F:receptor signaling protein activity; IEA:Compara. GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome. GO:0007243; P:intracellular protein kinase cascade; IEA:Compara. GO:0007265; P:Ras protein signal transduction; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |