CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019380
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat and IQ domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 LRRIQ1 
Gene Synonyms/Alias
 KIAA1801 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
581IIKDNQQKKIQKVEKacetylation[1]
582IKDNQQKKIQKVEKEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 DOMAIN 283 312 IQ 1.
 REPEAT 819 840 LRR 1.
 REPEAT 841 861 LRR 2.
 REPEAT 862 883 LRR 3.
 REPEAT 884 905 LRR 4.
 REPEAT 970 991 LRR 5.
 REPEAT 992 1013 LRR 6.
 REPEAT 1014 1035 LRR 7.
 REPEAT 1036 1057 LRR 8.
 REPEAT 1060 1081 LRR 9.
 REPEAT 1082 1103 LRR 10.
 DOMAIN 1117 1157 LRRCT.
 DOMAIN 1335 1364 IQ 2.
 DOMAIN 1395 1424 IQ 3.  
Keyword
 Alternative splicing; Complete proteome; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1722 AA 
Protein Sequence
MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP ESVLHCINII 60
KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS TEYEESSEQL IKILSEIEKE 120
EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL PDDADINFGY CEVEEKCRQS FEAWQEKQKE 180
LEDKEKQTLK AQRDREEKQF QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE 240
KIWKEKFKQH EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY 300
QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK KQKEEERKRR 360
EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL KKSGYNNKHL SLEDISNDKG 420
DIAKNLVDEN SKKQEDVLLW LVEESNMKEN VDRQTILKES IQVKLKESIS SQTILADFKM 480
EEKNENLAKK RCSEELVKQE RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI 540
MKHVINENTG QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK 600
DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA WNSGIVIFNT 660
TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE VNSLKSEIRN ISEKCHENAP 720
EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA 780
LDKLEILRCG PWDTLQQVTT VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK 840
KLKYIDAQEN HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY 900
SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS DCNFLISHLY 960
WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH NHLTDVEGVE NCGLLQILKL 1020
QGNYLSELPS LENLVLLREL HLDDNSISTV EAFSSYWLPL LQNITISQNS LTKIVPLFHF 1080
VSLEKLDVSH NCLSDLKSAI KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN 1140
GNILNSNSES RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY 1200
FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY SCAREGEPDS 1260
PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE DSKASSIPTI RIPFKEVVMT 1320
NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL MRRQTHFSTR LHTAATEGLP NSSIKNQTIL 1380
KKGKRENIVN IRKQREKAAI LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI 1440
FDEAALEEEW LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK 1500
ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD ISTAQQMLKR 1560
AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP RRDGYFEGIE EDPIHKDTTA 1620
NEKLERNREY TYQWLHTQVG VHETTSSRNM KCNHFLPELD PDVLNGGRVQ LVARLVSRED 1680
TDLDLFSMTN GSALSVNREK KNQAHRHSAG SSSKLWFPSK LI 1722 
Gene Ontology
  
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF12799; LRR_4 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ
 PS51450; LRR 
PRINTS