UniProt Accession

 ARP19_RAT; Q712U5 

Genbank Protein ID

 AJ005982; BC058461 

Genbank Nucleotide ID

 CAA06796.1; AAH58461.1 

Protein Name

 cAMP-regulated phosphoprotein 19 

Protein Synonyms/Alias

 ARPP-19 

Gene Name

 Arpp19 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
20	EQKEMEDKVTSPEKA	acetylation	[1]
42	RYPHLGQKPGGSDFL	acetylation	[1]
84	LPAAAPDKTEVTGDH	acetylation	[1]
102	PQDLPQRKPSLVASK	acetylation	[1]
109	KPSLVASKLAG****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine; in isoform ARPP-19 (By
 MOD_RES 17 17 N-acetylmethionine; in isoform ARPP-16
 MOD_RES 62 62 Phosphoserine; by GWL (Probable).
 MOD_RES 104 104 Phosphoserine; by PKA.
 MOD_RES 109 109 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Mitosis; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 112 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; ISS:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0008601; F:protein phosphatase type 2A regulator activity; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007212; P:dopamine receptor signaling pathway; IEP:RGD.
 GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
 GO:0007067; P:mitosis; ISS:UniProtKB.
 GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:RGD. 

Interpro

 IPR006760; Endosulphine. 

Pfam

 PF04667; Endosulfine 

SMART

  

PROSITE

  

PRINTS