UniProt Accession

 F162A_MOUSE; Q9D6U8 

Genbank Protein ID

 AK009946; BC010826 

Genbank Nucleotide ID

 BAB26601.1; AAH10826.1 

Protein Name

 Protein FAM162A 

Protein Synonyms/Alias

 E2-induced gene 5 protein homolog; Growth and transformation-dependent protein; HGTD-P 

Gene Name

 Fam162a 

Gene Synonyms/Alias

 E2ig5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	RHGVPLHKPTDFEKK	acetylation	[1, 2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. 

Sequence Annotation

 REGION 77 103 Required for proapoptotic activity (By  

Keyword

 Apoptosis; Complete proteome; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
 GO:0051402; P:neuron apoptotic process; IDA:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB.
 GO:0006927; P:transformed cell apoptotic process; IEA:Compara. 

Interpro

 IPR009432; DUF1075. 

Pfam

 PF06388; DUF1075 

SMART

  

PROSITE

  

PRINTS