CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014762
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 1-delta 
Protein Synonyms/Alias
 EF-1-delta 
Gene Name
 Eef1d 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
17KIWFDKFKYDDAERRacetylation[1]
107DLQQAISKLEVRLSTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (By similarity). 
Sequence Annotation
 REGION 80 115 Leucine-zipper (By similarity).
 REGION 173 281 Catalytic (GEF) (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 17 17 N6-acetyllysine (By similarity).
 MOD_RES 107 107 N6-acetyllysine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 129 129 Phosphothreonine (By similarity).
 MOD_RES 133 133 Phosphoserine (By similarity).
 MOD_RES 147 147 Phosphothreonine (By similarity).
 MOD_RES 162 162 Phosphoserine; by CK2.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Elongation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 281 AA 
Protein Sequence
MATNFLMHEK IWFDKFKYDD AERRFYEQMN GPVTAGSRQE NGASVILRDI ARARENIQKS 60
LAGSSGPGAS SGPGGDHSDL IVRIASLEVE NQNLRGVVQD LQQAISKLEV RLSTLEKSSP 120
THRATAPQTQ HVSPMRQVEP PAKKGATPAE DDEDNDIDLF GSDEEEEDKE AARLREERLR 180
QYAEKKAKKP TLVAKSSILL DVKPWDDETD MAQLETCVRS IQLDGLVWGA SKLVPVGYGI 240
RKLQIQCVVE DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I 281 
Gene Ontology
 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018940; EF-1_beta_acid_region_euk.
 IPR014717; Transl_elong_EF1B/ribosomal_S6.
 IPR001326; Transl_elong_EF1B_B/D_CS.
 IPR014038; Transl_elong_fac_EF1B_bsu/dsu. 
Pfam
 PF10587; EF-1_beta_acid
 PF00736; EF1_GNE 
SMART
 SM00888; EF1_GNE 
PROSITE
 PS00825; EF1BD_2 
PRINTS