CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Semaphorin-4C 
Protein Synonyms/Alias
  
Gene Name
 SEMA4C 
Gene Synonyms/Alias
 KIAA1739; SEMAI; UNQ5855/PRO34487 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
395DNILNFVKKHPLMEEubiquitination[1]
744YYSDGSLKIVPGHARubiquitination[2, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. 
Sequence Annotation
 DOMAIN 30 497 Sema.
 DOMAIN 499 551 PSI.
 DOMAIN 556 644 Ig-like C2-type.
 REGION 46 489 Dominant negative effect on myogenic
 MOTIF 830 833 PDZ-binding.
 CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...) (Potential).
 CARBOHYD 564 564 N-linked (GlcNAc...) (Potential).
 DISULFID 99 110 By similarity.
 DISULFID 128 137 By similarity.
 DISULFID 261 370 By similarity.
 DISULFID 285 330 By similarity.
 DISULFID 500 517 By similarity.
 DISULFID 509 526 By similarity.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Postsynaptic cell membrane; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 833 AA 
Protein Sequence
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE 60
PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI QKGKNNQTEC FNFIRFLQPY 120
NASHLYVCGT YAFQPKCTYV NMLTFTLEHG EFEDGKGKCP YDPAKGHAGL LVDGELYSAT 180
LNNFLGTEPI ILRNMGPHHS MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR 240
ERAVESDCYA EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 300
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE EAQKWDRYTD 360
PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM EEQVGPRWSR PLLVKKGTNF 420
THLVADRVTG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQLFDQE PMRSLVLSQS 480
KKLLFAGSRS QLVQLPVADC MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH 540
VMTSDTSGIC NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 600
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS VTLEARAPLE 660
NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA TERTLVYPLE LPKEPTSPPF 720
RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG 780
GRNSNANGYV RLQLGGEDRG GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV 833 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0021535; P:cell migration in hindbrain; ISS:UniProtKB.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0042692; P:muscle cell differentiation; IDA:UniProtKB.
 GO:0001843; P:neural tube closure; ISS:UniProtKB.
 GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:UniProtKB.
 GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002165; Plexin_repeat.
 IPR027231; Semaphorin.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF01437; PSI
 PF01403; Sema 
SMART
 SM00409; IG
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS50835; IG_LIKE
 PS51004; SEMA 
PRINTS