CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017261
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DCC-interacting protein 13-beta 
Protein Synonyms/Alias
 Dip13-beta; Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 
Gene Name
 Appl2 
Gene Synonyms/Alias
 Dip13b; Dip3b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
280INRNLIQKTGYLNLRubiquitination[1]
406TPITSFGKKQESSCSubiquitination[1]
618KEIIEVQKDPEALARubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity). 
Sequence Annotation
 DOMAIN 277 375 PH.
 DOMAIN 486 635 PID.
 REGION 1 428 Required for RAB5A binding (By  
Keyword
 Cell cycle; Complete proteome; Endosome; Membrane; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 662 AA 
Protein Sequence
MPAVDKLLLE EALQDSPQAR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA QNEMCLATQQ 60
LSRQLLAYEK QNFALGKGDE EVISTLHYFS KVMDELNGLH TELAKQLADT MVLPVIQFRE 120
KDLTEVSTLK DLFGLASSEH DLSMAKYSRL PKKKENEKAK TEIVKEVAAA RRKQHLSSLQ 180
YYCALNALQY RKRAAMMEPL IGFAHGQINF FKRGAEMFSK SMDGFLSSVK DMVQSIQVEL 240
EAEADKMRVS QQELLSVSES VYTPDIDVAT AQINRNLIQK TGYLNLRNKT GLVTTTWERL 300
YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQISTPSGK PGIILQAESR 360
KEYEEWICAV NNISRQIYLT DNPEAVAIKL NQTALQAVTP ITSFGKKQES SCSSQNIKNS 420
DIEDDNIVPK ATASIPETEE LIAPGTPIQF DIVLPATEFL DQNRGGRRTN PFGETEDGSF 480
PEAEDSLLQQ MFIVRFLGSM AVKTDSTAEV IYEAMRQVLA ARAIHNIFRM TESHLMVTSQ 540
TLRLIDPQTQ VSRACFELTS VTQFAAHQEN KRLVGFVIRV PESTGEESLS TYIFESNSEG 600
EKICYAINLG KEIIEVQKDP EALARLMLSV PLTNDGKYVL LNDQADDTGG SPSENRGAES 660
EA 662 
Gene Ontology
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; ISS:UniProtKB. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR006020; PTyr_interaction_dom. 
Pfam
 PF00640; PID 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN
 PS01179; PID 
PRINTS