UniProt Accession

 NUDT6_HUMAN; P53370; A8K756; O95097; Q9UQD9 

Genbank Protein ID

 AF019633; AF019632; AK291871; BC009842; L31408 

Genbank Nucleotide ID

 AAD01636.2; AAD01635.1; BAF84560.1; AAH09842.1; AAA67062.1 

Protein Name

 Nucleoside diphosphate-linked moiety X motif 6 

Protein Synonyms/Alias

 Nudix motif 6; Antisense basic fibroblast growth factor; Protein GFG 

Gene Name

 NUDT6 

Gene Synonyms/Alias

 FGF2AS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	LDAAAFQKGLQAAVQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May contribute to the regulation of cell proliferation. 

Sequence Annotation

 DOMAIN 141 273 Nudix hydrolase.
 MOTIF 176 197 Nudix box.
 CROSSLNK 76 76 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Isopeptide bond; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008083; F:growth factor activity; TAS:UniProtKB.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 

Interpro

 IPR003293; Nudix_hydrolase6-like.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR01356; GFGPROTEIN.