UniProt Accession

 CREB5_HUMAN; Q02930; A8KA51; B4DU13; B5BUH3; C9JK47; Q05886; Q06246; Q75N02; Q86UJ9 

Genbank Protein ID

 L05515; L05911; L05912; L05913; AK292916; AK300455; AK316187; AB451409; AC003074; AC005105; AC005013; AC006331; AC006367; AC006980; CH471073; CH471073; BC059400 

Genbank Nucleotide ID

 AAA52072.1; AAC37525.1; AAC37527.1; AAC37526.1; BAF85605.1; BAG62175.1; BAH14558.1; BAG70223.1; AAS00387.1; AAP22329.1; EAW93908.1; EAW93910.1; AAH59400.2 

Protein Name

 Cyclic AMP-responsive element-binding protein 5 

Protein Synonyms/Alias

 CREB-5; cAMP-responsive element-binding protein 5; CRE-BPa 

Gene Name

 CREB5 

Gene Synonyms/Alias

 CREBPA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
432	KNEVAQLKQLLLTHK	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds to the cAMP response element and activates transcription. 

Sequence Annotation

 DOMAIN 375 438 bZIP.
 ZN_FING 16 40 C2H2-type.
 REGION 377 397 Basic motif (By similarity).
 REGION 403 431 Leucine-zipper (By similarity).
 MOD_RES 59 59 Phosphothreonine.
 MOD_RES 61 61 Phosphothreonine.
 MOD_RES 137 137 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060612; P:adipose tissue development; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR004827; bZIP.
 IPR016378; TF_cAMP-dep.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ
 SM00355; ZnF_C2H2 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS