UniProt Accession

 D4I9D8_ERWAE; D4I9D8 

Genbank Protein ID

 FN666575 

Genbank Nucleotide ID

 CBJ47307.1 

Protein Name

 S-ribosylhomocysteine lyase 

Protein Synonyms/Alias

 AI-2 synthesis protein; Autoinducer-2 production protein LuxS 

Gene Name

 luxS 

Gene Synonyms/Alias

 EAM_2633 

Created Date

 July 27, 2013 

Organism

 Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3) 

NCBI Taxa ID

 716540 

Lysine Modification

Position	Peptide	Type	References
149	IARHIIEKDIRVNRN	acetylation	[1]

Reference

 [1] Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics.
 Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y.
 J Proteomics. 2013 Feb 21;79:60-71. [PMID: 23234799] 

Functional Description

 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity). 

Sequence Annotation

 METAL 54 54 Iron (By similarity).
 METAL 58 58 Iron (By similarity).
 METAL 128 128 Iron (By similarity).  

Keyword

 Autoinducer synthesis; Complete proteome; Iron; Lyase; Metal-binding; Quorum sensing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0043768; F:S-ribosylhomocysteine lyase activity; IEA:HAMAP.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0009372; P:quorum sensing; IEA:HAMAP. 

Interpro

 IPR011249; Metalloenz_LuxS/M16.
 IPR003815; S-ribosylhomocysteinase. 

Pfam

 PF02664; LuxS 

SMART

  

PROSITE

  

PRINTS

 PR01487; LUXSPROTEIN.