CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Excitatory amino acid transporter 1 
Protein Synonyms/Alias
 Solute carrier family 1 (Glial high affinity glutamate transporter), member 3, isoform CRA_a 
Gene Name
 Slc1a3 
Gene Synonyms/Alias
 rCG_50959 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
521IEENEMKKPYQLIAQacetylation[1]
521IEENEMKKPYQLIAQubiquitination[2]
534AQDNEPEKPVADSETacetylation[1]
534AQDNEPEKPVADSETubiquitination[2]
542PVADSETKM******ubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 543 AA 
Protein Sequence
MTKSNGEEPR MGSRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF VLLTVSAVIV 60
GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG 120
MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMYREGK IVQVTAADAF LDLIRNMFPP 180
NLVEACFKQF KTSYEKRSFK VPIQANETLL GAVINNVSEA METLTRIREE MVPVPGSVNG 240
VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK 300
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL 360
GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD GTALYEALAA IFIAQVNNFD 420
LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT 480
TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE 540
TKM 543 
Gene Ontology
 GO:0042995; C:cell projection; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0043205; C:fibril; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0016595; F:glutamate binding; IEA:Compara.
 GO:0005314; F:high-affinity glutamate transmembrane transporter activity; IEA:Compara.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro.
 GO:0031223; P:auditory behavior; IEA:Compara.
 GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:Compara.
 GO:0021545; P:cranial nerve development; IEA:Compara.
 GO:0070779; P:D-aspartate import; IEA:Compara.
 GO:0009449; P:gamma-aminobutyric acid biosynthetic process; IEA:Compara.
 GO:0006537; P:glutamate biosynthetic process; IEA:Compara.
 GO:0051938; P:L-glutamate import; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0050806; P:positive regulation of synaptic transmission; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009416; P:response to light stimulus; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 
Interpro
 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 
Pfam
 PF00375; SDF 
SMART
  
PROSITE
 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 
PRINTS
 PR00173; EDTRNSPORT.