UniProt Accession

 NOLC1_HUMAN; Q14978; Q15030; Q5VV70; Q9BUV3 

Genbank Protein ID

 Z34289; AY820769; AL500527; CH471066; CH471066; BC001883; D21262 

Genbank Nucleotide ID

 CAA84063.1; AAV67777.1; CAH72220.1; EAW49714.1; EAW49715.1; AAH01883.1; BAA04803.1 

Protein Name

 Nucleolar and coiled-body phosphoprotein 1 

Protein Synonyms/Alias

 140 kDa nucleolar phosphoprotein; Nopp140; Hepatitis C virus NS5A-transactivated protein 13; HCV NS5A-transactivated protein 13; Nucleolar 130 kDa protein; Nucleolar phosphoprotein p130 

Gene Name

 NOLC1 

Gene Synonyms/Alias

 KIAA0035; NS5ATP13 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	QLSEVANKFAKATGA	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I. 

Sequence Annotation

 DOMAIN 10 42 LisH.
 REPEAT 84 95 Acidic serine cluster 1.
 REPEAT 125 136 Acidic serine cluster 2.
 REPEAT 167 178 Acidic serine cluster 3.
 REPEAT 221 232 Acidic serine cluster 4.
 REPEAT 264 275 Acidic serine cluster 5.
 REPEAT 325 336 Acidic serine cluster 6.
 REPEAT 363 375 Acidic serine cluster 7.
 REPEAT 425 436 Acidic serine cluster 8.
 REPEAT 470 481 Acidic serine cluster 9.
 REPEAT 519 529 Acidic serine cluster 10.
 REPEAT 555 566 Acidic serine cluster 11.
 REGION 84 566 11 X 12 AA approximate repeats of an
 REGION 204 382 Interacts with RPA194.
 MOTIF 68 82 Nuclear localization signal (Potential).
 MOTIF 384 587 Nuclear localization signal (Potential).
 MOTIF 601 617 Nuclear localization signal (Potential).
 MOD_RES 33 33 N6-acetyllysine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 90 90 Phosphoserine.
 MOD_RES 91 91 Phosphoserine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 397 397 Phosphoserine.
 MOD_RES 415 415 N6-acetyllysine.
 MOD_RES 508 508 Phosphoserine.
 MOD_RES 538 538 Phosphoserine.
 MOD_RES 563 563 Phosphoserine.
 MOD_RES 580 580 Phosphoserine.
 MOD_RES 582 582 Phosphoserine.
 MOD_RES 607 607 Phosphothreonine.
 MOD_RES 610 610 Phosphothreonine.
 MOD_RES 622 622 Phosphoserine.
 MOD_RES 643 643 Phosphoserine.
 MOD_RES 663 663 N6-acetyllysine.
 MOD_RES 686 686 Phosphoserine.
 MOD_RES 698 698 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 699 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; TAS:ProtInc.
 GO:0007000; P:nucleolus organization; IEA:Compara.
 GO:0006364; P:rRNA processing; TAS:ProtInc. 

Interpro

 IPR006594; LisH_dimerisation.
 IPR007718; SRP40_C. 

Pfam

 PF05022; SRP40_C 

SMART

 SM00667; LisH 

PROSITE

 PS50896; LISH 

PRINTS