UniProt Accession

 GCSAM_HUMAN; Q8N6F7; C9JD17; C9JUG6 

Genbank Protein ID

 AY212246; AF521911; AC128688; BC030506; BM456595 

Genbank Nucleotide ID

 AAO22147.1; AAO21701.1; AAH30506.1 

Protein Name

 Germinal center-associated signaling and motility protein 

Protein Synonyms/Alias

 Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL 

Gene Name

 GCSAM 

Gene Synonyms/Alias

 GAL; GCET2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	KKILIFEKRQDSQNE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. 

Sequence Annotation

 MOD_RES 148 148 Phosphotyrosine.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:2000402; P:negative regulation of lymphocyte migration; IMP:UniProtKB. 

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