UniProt Accession

 CENPL_HUMAN; Q8N0S6; Q5TEL5; Q96ND4 

Genbank Protein ID

 AK055606; AL109921; AL109921; BC007071; BC033154; BC066658 

Genbank Nucleotide ID

 BAB70968.1; CAI20378.1; CAI20379.1; AAH07071.1; AAH33154.1; AAH66658.1 

Protein Name

 Centromere protein L 

Protein Synonyms/Alias

 CENP-L; Interphase centromere complex protein 33 

Gene Name

 CENPL 

Gene Synonyms/Alias

 C1orf155; ICEN33 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	QEDVDPQKVAFLLHK	ubiquitination	[1, 2]
89	KFSYSNLKEYSRLLN	ubiquitination	[1]
367	AHTDGKIKILCHKYL	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. 

Sequence Annotation

 MOD_RES 53 53 Phosphoserine.  

Keyword

 Alternative splicing; Centromere; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 

Interpro

 IPR025204; CAD_CENP-L. 

Pfam

 PF13092; CENP-L 

SMART

  

PROSITE

  

PRINTS