CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angiogenic factor with G patch and FHA domains 1 
Protein Synonyms/Alias
 Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein 
Gene Name
 AGGF1 
Gene Synonyms/Alias
 GPATC7; GPATCH7; VG5Q 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
622SEITDSNKGRKMLEKacetylation[1]
664HAGLGTGKPSSFEDVacetylation[2, 3, 4]
679HLLQNKNKKNWDKARacetylation[5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. 
Sequence Annotation
 DOMAIN 434 487 FHA.
 DOMAIN 619 665 G-patch.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 664 664 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Angiogenesis; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Disease mutation; Polymorphism; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 714 AA 
Protein Sequence
MASEAPSPPR SPPPPTSPEP ELAQLRRKVE KLERELRSCK RQVREIEKLL HHTERLYQNA 60
ESNNQELRTQ VEELSKILQR GRNEDNKKSD VEVQTENHAP WSISDYFYQT YYNDVSLPNK 120
VTELSDQQDQ AIETSILNSK DHLQVENDAY PGTDRTENVK YRQVDHFASN SQEPASALAT 180
EDTSLEGSSL AESLRAAAEA AVSQTGFSYD ENTGLYFDHS TGFYYDSENQ LYYDPSTGIY 240
YYCDVESGRY QFHSRVDLQP YPTSSTKQSK DKKLKKKRKD PDSSATNEEK DLNSEDQKAF 300
SVEHTSCNEE ENFANMKKKA KIGIHHKNSP PKVTVPTSGN TIESPLHENI SNSTSFKDEK 360
IMETDSEPEE GEITDSQTED SYDEAITSEG NVTAEDSEDE DEDKIWPPCI RVIVIRSPVL 420
QIGSLFIITA VNPATIGREK DMEHTLRIPE VGVSKFHAEI YFDHDLQSYV LVDQGSQNGT 480
IVNGKQILQP KTKCDPYVLE HGDEVKIGET VLSFHIHPGS DTCDGCEPGQ VRAHLRLDKK 540
DESFVGPTLS KEEKELERRK ELKKIRVKYG LQNTEYEDEK TLKNPKYKDR AGKRREQVGS 600
EGTFQRDDAP ASVHSEITDS NKGRKMLEKM GWKKGEGLGK DGGGMKTPIQ LQLRRTHAGL 660
GTGKPSSFED VHLLQNKNKK NWDKARERFT ENFPETKPQK DDPGTMPWVK GTLE 714 
Gene Ontology
 GO:0005576; C:extracellular region; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IDA:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
 GO:0006396; P:RNA processing; TAS:UniProtKB.
 GO:0001570; P:vasculogenesis; TAS:UniProtKB. 
Interpro
 IPR000253; FHA_dom.
 IPR000467; G_patch_dom.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA
 PF01585; G-patch 
SMART
 SM00240; FHA
 SM00443; G_patch 
PROSITE
 PS50006; FHA_DOMAIN
 PS50174; G_PATCH 
PRINTS