UniProt Accession

 ARPC2_RAT; P85970 

Genbank Protein ID

 AABR03068131; AABR03068820; AABR03069184 

Genbank Nucleotide ID

  

Protein Name

 Actin-related protein 2/3 complex subunit 2 

Protein Synonyms/Alias

 Arp2/3 complex 34 kDa subunit; p34-ARC 

Gene Name

 Arpc2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
65	SISLKFYKELQAHGA	acetylation	[1]
77	HGADELLKRVYGSFL	acetylation	[1]
117	VHQAGMLKRNCFASV	acetylation	[1]
136	FQFQEEGKEGENRAV	acetylation	[1]
186	KVFMQEFKEGRRASH	acetylation	[1]
269	IHTRMRAKTSDFLKV	acetylation	[1]
275	AKTSDFLKVLNRARP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). 

Sequence Annotation

 MOD_RES 275 275 N6-acetyllysine (By similarity).
 MOD_RES 295 295 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0035650; F:AP-1 adaptor complex binding; IDA:MGI.
 GO:0071933; F:Arp2/3 complex binding; IDA:MGI.
 GO:0019894; F:kinesin binding; IDA:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Compara. 

Interpro

 IPR007188; P34-arc. 

Pfam

 PF04045; P34-Arc 

SMART

  

PROSITE

  

PRINTS