CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate dehydrogenase 2 
Protein Synonyms/Alias
 GDH-2 
Gene Name
 gdhA-2 
Gene Synonyms/Alias
 gdhA; SSO1907 
Created Date
 July 27, 2013 
Organism
 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322  
NCBI Taxa ID
 273057 
Lysine Modification
Position
Peptide
Type
References
254KGGVINEKGIDVGKAmethylation[1]
260EKGIDVGKAIEIKEKmethylation[1]
372ISDEEAKKLIVDRMNmethylation[1]
391TLYDYHQKKLEDHDLmethylation[1]
392LYDYHQKKLEDHDLRmethylation[1]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 
Functional Description
  
Sequence Annotation
 ACT_SITE 109 109 By similarity.
 MOD_RES 2 2 N-acetylmethionine.
 MOD_RES 254 254 N6-methyllysine.
 MOD_RES 260 260 N6-methyllysine.
 MOD_RES 372 372 N6-methyllysine.
 MOD_RES 391 391 N6-methyllysine.
 MOD_RES 392 392 N6-methyllysine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Methylation; NAD; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MMEEVLSSSL YTQQVKKLYK VGELLGLDNE TLETLSQPER IIQVKIQIRG SDGKLKTFMG 60
WRSQHNSALG PYKGGVRYHP NVTQDEVEAL SMIMTWKNSL LLLPYGGGKG GVRVDPKKLT 120
REELEQLSRK YIQAIYKYLG SELDIPAPDV NTDSQTMAWF LDEYIKITGK VDFAVFTGKP 180
VELGGIGVRL YSTGLGVATI AKEAANKFIG GVEEARVIIQ GFGNVGYYAG KFLSEMGAKI 240
VGVSDSKGGV INEKGIDVGK AIEIKEKTGS VINYPEGRKV TNEELLISDC DILIPAALEN 300
VINKFNAPKV KAKLIVEGAN GPLTADADEI MRQRGIAVVP DILANAGGVV GSYVEWANNK 360
MGEIISDEEA KKLIVDRMNN AFNTLYDYHQ KKLEDHDLRT AAMALAVDRV VRAMKARGIL 420 
Gene Ontology
 GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; IEA:EC.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. 
Interpro
 IPR006095; Glu/Leu/Phe/Val_DH.
 IPR006096; Glu/Leu/Phe/Val_DH_C.
 IPR006097; Glu/Leu/Phe/Val_DH_dimer_dom.
 IPR014362; Glu_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00208; ELFV_dehydrog
 PF02812; ELFV_dehydrog_N 
SMART
 SM00839; ELFV_dehydrog 
PROSITE
 PS00074; GLFV_DEHYDROGENASE 
PRINTS
 PR00082; GLFDHDRGNASE.