CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor subfamily 4 group A member 2 
Protein Synonyms/Alias
 Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor 
Gene Name
 NR4A2 
Gene Synonyms/Alias
 NOT; NURR1; TINUR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91SGQQSSIKVEDIQMHsumoylation[1]
577LQRIFYLKLEDLVPPsumoylation[1]
Reference
 [1] PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.
 Galleguillos D, Vecchiola A, Fuentealba JA, Ojeda V, Alvarez K, Gómez A, Andrés ME.
 J Biol Chem. 2004 Jan 16;279(3):2005-11. [PMID: 14559918] 
Functional Description
 Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). 
Sequence Annotation
 DNA_BIND 260 335 Nuclear receptor.
 ZN_FING 263 283 NR C4-type.
 ZN_FING 299 323 NR C4-type.
 REGION 409 459 Ligand-binding (Potential).
 MOTIF 287 314 Bipartite nuclear localization signal
 MOTIF 338 350 Nuclear localization signal (NLS1).
 MOTIF 443 452 nuclear export sequence (NES1).
 MOTIF 568 577 nuclear export sequence (NES2).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF 60
STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV 120
YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ 180
SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA 240
SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 300
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP 360
PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW 420
AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG 480
EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT 540
FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF 598 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI.
 GO:0033554; P:cellular response to stress; IEA:Compara.
 GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Compara.
 GO:0016265; P:death; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IEA:Compara.
 GO:0071542; P:dopaminergic neuron differentiation; ISS:UniProtKB.
 GO:0021986; P:habenula development; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0042551; P:neuron maturation; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0043085; P:positive regulation of catalytic activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0042053; P:regulation of dopamine metabolic process; IEA:Compara.
 GO:0043576; P:regulation of respiratory gaseous exchange; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010035; P:response to inorganic substance; IEA:Compara.
 GO:0017085; P:response to insecticide; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 
Interpro
 IPR003070; Nuc_orph_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR003073; NURR_rcpt.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01284; NUCLEARECPTR.
 PR01287; NURRNUCRCPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.