CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal-induced proliferation-associated 1-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 SIPA1L1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
262FRDFLLAKVINAENAubiquitination[1]
272NAENAAHKSEKFRAMubiquitination[2]
275NAAHKSEKFRAMATRubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1257 AA 
Protein Sequence
MKENGSPYNY RIIFRTSELM TLRGSVLEDA IPSTAKHSTA RGLPLKEVLE HVVPELNVQC 60
LRLAFNTPKV TEQLMKLDEQ GLNYQQKVGI MYCKAGQSTE EEMYNNESAG PAFEEFLQLL 120
GERVRLKGFE KYRAQLDTKT DSTGTHSLYT TYKDYEIMFH VSTMLPYTPN NKQQLLRKRH 180
IGNDIVTIVF QEPGAQPFSP KNIRSHFQHV FVIVRVHNPC SDSVCYSVAV TRSRDVPSFG 240
PPIPKGVTFP KSNVFRDFLL AKVINAENAA HKSEKFRAMA TRTRQEYLKD LAEKNVTNTP 300
IDPSGKFPFI SLASKKKEKS KPYPGAELSS MGAIVWAVRA EDYNKAMELD CLLGISNEFI 360
VLIEQETKSV VFNCSCRDVI GWTSTDTSLK IFYERGECVS VGSFINIEEI KEIVKRLQFV 420
SKGCESVEMT LRRNGLGQLG FHVNYEGIVA DVEPYGYAWQ AGLRQGSRLV EICKVAVATL 480
SHEQMIDLLR TSVTVKVVII PPHDDCTPRR SCSETYRMPV MEYKMNEGVS YEFKFPFRNN 540
NKWQRNASKG PHSPQVPSQV QSPMTSRLNA GKGDGKMPPP ERAANIPRSI SSDGRPLERR 600
LSPGSDIYVT VSSMALARSQ CRNSPSNLSS SSDTGSVGGT YRQKSMPEGF GVSRRSPASI 660
DRQNTQSDIG GSGKSTPSWQ RSEDSIADQM EPTCHLPAVS KVLPAFRESP SGRLMRQDPV 720
VHLSPNKQGH SDSHYSSHSS SNTLSSNASS AHSDEKWYDG DRTESELNSY NYLQGTSADS 780
GIDTTSYGPS HGSTASLGAA TSSPRSGPGK EKVAPLWHSS SEVISMADRT LETESHGLDR 840
KTESSLSLDI HSKSQAGSTP LTRENSTFSI NDAASHTSTM SSRHSASPVV FTSARSSPKE 900
ELHPAAPSQL APSFSSSSSS SSGPRSFYPR QGATSKYLIG WKKPEGTINS VGFMDTRKRH 960
QSDGNEIAHT RLRASTRDLR ASPKPTSKST IEEDLKKLID LESPTPESQK SFKFHALSSP 1020
QSPFPSTPTS RRALHRTLSD ESIYNSQREH FFTSRASLLD QALPNDVLFS STYPSLPKSL 1080
PLRRPSYTLG MKSLHGEFSA SDSSLTDIQE TRRQPMPDPG LMPLPDTAAD LDWSNLVDAA 1140
KAYEVQRASF FAASDENHRP LSAASNSDQL EDQALAQMKP YSSKDSSPTL ASKVDQLEGM 1200
LKMLREDLKK EKEDKAHLQA EVQHLREDNL RLQEESQNAS DKLKKFTEWV FNTIDMS 1257 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR021818; DUF3401.
 IPR001478; PDZ.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF11881; DUF3401
 PF00595; PDZ
 PF02145; Rap_GAP 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ
 PS50085; RAPGAP 
PRINTS