CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017516
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ARL14 effector protein 
Protein Synonyms/Alias
 ARF7 effector protein 
Gene Name
 ARL14EP 
Gene Synonyms/Alias
 ARF7EP; C11orf46 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19RTTNECHKTYYTRHTubiquitination[1]
84DPFNIHKKLAKKNLHubiquitination[1]
88IHKKLAKKNLHVIDLubiquitination[1]
104DATFLSAKFGRQLVPubiquitination[1, 2, 3, 4]
114RQLVPGWKLCPKCTQubiquitination[1]
118PGWKLCPKCTQIINGubiquitination[1]
169EFAPETGKREKRRLTubiquitination[1]
191DRQVIPAKSKVYDSQubiquitination[1]
193QVIPAKSKVYDSQGLubiquitination[1]
257GGEIIHNKHAG****ubiquitination[1, 5, 6, 7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 260 AA 
Protein Sequence
MMDPCSVGVQ LRTTNECHKT YYTRHTGFKT LQELSSNDML LLQLRTGMTL SGNNTICFHH 60
VKIYIDRFED LQKSCCDPFN IHKKLAKKNL HVIDLDDATF LSAKFGRQLV PGWKLCPKCT 120
QIINGSVDVD TEDRQKRKPE SDGRTAKALR SLQFTNPGRQ TEFAPETGKR EKRRLTKNAT 180
AGSDRQVIPA KSKVYDSQGL LIFSGMDLCD CLDEDCLGCF YACPACGSTK CGAECRCDRK 240
WLYEQIEIEG GEIIHNKHAG 260 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. 
Interpro
 IPR026515; ARF7EP. 
Pfam
  
SMART
  
PROSITE
  
PRINTS